Large (film)

Large is a 2001 feature film directed by Justin Edgar for FilmFour.

Plot

Large is a gross-out teen comedy which centres on Jason, the son of a fading rock star, and his comic attempts to fulfill the conditions of his father's will in order to inherit a fortune.

Cast

Luke de Woolfson as Jason Mouseley
Simon Lowe as Rob
Phil Cornwell as Barry Blaze Mouseley
Melanie Gutteridge as Sophie
Morwenna Banks as Lorraine
Lee Oakes as Ian
Andrew Grainger as Norman Gates

Production

Large was produced by Alex Usburne.The pre-production period was relatively long, with writers Mike Dent and Justin Edgar draughting 20 versions of the script.Large was filmed and edited at Pebble Mill Studios and on location in Birmingham, UK, for six weeks in March and April 2000 on a budget of £1.4 million. The line producer was Paul Ritchie (Slumdog Millionaire, Bend It Like Beckham). It was the first film of Director of Photography Robbie Ryan (Fish Tank, Wuthering Heights) and Editor Eddie Hamilton (Kick Ass, X-Men: First Class). It was also Edgar's feature film debut.

Large set (Ramsey theory)

In Ramsey theory, a set S of natural numbers is considered to be a large set if and only if Van der Waerden's theorem can be generalized to assert the existence of arithmetic progressions with common difference in S. That is, S is large if and only if every finite partition of the natural numbers has a cell containing arbitrarily long arithmetic progressions having common differences in S.

Examples

Properties

Necessary conditions for largeness include:

If is large, it is not the case that s_k≥3s_k-1 for k≥ 2.

Two sufficient conditions are:

If where is a polynomial with and positive leading coefficient, then is large.

The first sufficient condition implies that if S is a thick set, then S is large.

Other facts about large sets include:

LARGE

Glycosyltransferase-like protein LARGE1 is an enzyme that in humans is encoded by the LARGE gene.

Function

This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. The exact function of LARGE, a golgi protein, remains uncertain. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

LARGE may also play a role in tumor-specific genomic rearrangements. Mutations in this gene may be involved in the development and progression of meningioma through modification of ganglioside composition and other glycosylated molecules in tumor cells.

Program management

Program management or programme management is the process of managing several related projects, often with the intention of improving an organization's performance. In practice and in its aims it is often closely related to systems engineering and industrial engineering.

The program manager has oversight of the purpose and status of the projects in a program and can use this oversight to support project-level activity to ensure the program goals are met by providing a decision-making capacity that cannot be achieved at project level or by providing the project manager with a program perspective when required, or as a sounding board for ideas and approaches to solving project issues that have program impacts. In a program there is a need to identify and manage cross-project dependencies and often the project management office (PMO) may not have sufficient insight of the risk, issues, requirements, design or solution to be able to usefully manage these. The program manager may be well placed to provide this insight by actively seeking out such information from the project managers although in large and/or complex projects, a specific role may be required. However this insight arises, the program manager needs this in order to be comfortable that the overall program goals are achievable.

Program (machine)

A program is a set of instructions used to control the behavior of a machine, often a computer (in this case it is known as a computer program).

Examples of programs include:

The execution of a program is a series of actions following the instructions it contains. Each instruction produces effects that alter the state of the machine according to its predefined meaning.

While some machines are called programmable, for example a programmable thermostat or a musical synthesizer, they are in fact just devices which allow their users to select among a fixed set of a variety of options, rather than being controlled by programs written in a language (be it textual, visual or otherwise).

Computer program

A computer program is a collection of instructions that performs a specific task when executed by a computer. A computer requires programs to function, and typically executes the program's instructions in a central processing unit.

A computer program is usually written by a computer programmer in a programming language. From the program in its human-readable form of source code, a compiler can derive machine code—a form consisting of instructions that the computer can directly execute. Alternatively, a computer program may be executed with the aid of an interpreter.

A part of a computer program that performs a well-defined task is known as an algorithm. A collection of computer programs, libraries and related data are referred to as software. Computer programs may be categorized along functional lines, such as application software or system software.

History

Early programmable machines

The earliest programmable machines preceded the invention of the digital computer. In 1801, Joseph-Marie Jacquard devised a loom that would weave a pattern by following a series of perforated cards. Patterns, including flowers and leaves, could be weaved and repeated by arranging the cards.